期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 113, 期 45, 页码 12844-12849出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1615104113
关键词
diabetes; resistant starch biosynthesis; soluble starch synthase; granule-bound starch synthase; amylose-lipid complex
资金
- Ministry of Science and Technology [2013CBA014, 2014AA10A6, 2014ZX08001]
- Chinese Academy of Sciences [XDA08030101]
- State Key Laboratory of Plant Genomics [2014B0227-01, 2015B0129-01]
- High-End Program of Foreign Experts and Chinese Academy of Sciences Senior International Scientist Visiting Professorship [2013T1S0013]
Changes in human lifestyle and food consumption have resulted in a large increase in the incidence of type-2 diabetes, obesity, and colon disease, especially in Asia. These conditions are a growing threat to human health, but consumption of foods high in resistant starch (RS) can potentially reduce their incidence. Strategies to increase RS in rice are limited by a lack of knowledge of its molecular basis. Through map-based cloning of a RS locus in indica rice, we have identified a defective soluble starch synthase gene (SSIIIa) responsible for RS production and further showed that RS production is dependent on the high expression of the Waxy(a) (Wx(a)) allele, which is prevalent in indica varieties. The resulting RS has modified granule structure; high amylose, lipid, and amylose-lipid complex; and altered physicochemical properties. This discovery provides an opportunity to increase RS content of cooked rice, especially in the indica varieties, which predominates in southern Asia.
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