期刊
CHINESE JOURNAL OF CHEMICAL PHYSICS
卷 28, 期 2, 页码 193-196出版社
CHINESE PHYSICAL SOC
DOI: 10.1063/1674-0068/28/cjcp1411191
关键词
Hollow Fe3O4 nanoparticles; 3-Aminopropyltrimethoxy silane; Drug delivery
资金
- Project of Scientific Research of Zhejiang Gongshang University [1110KU114028]
Novel hollow Fe3O4 nanoparticles for drug delivery were synthesized via a one-step template-free approach. These nanoparticles were obtained by modifing the Fe3O4 nanoparticles with 3-aminopropyltrimethoxy silane, and then grafting alginate onto the surface of amine magnetic. The hollow structure of Fe3O4 spheres was characterized by TEM, XRD, and XPS. The M-H hysteresis loop indicated that the magnetic spheres exhibit superparamagnetic characteristics at room temperature. Daunorubicin acting as a model drug was loaded into the carrier, and the maximum percent of envelop and load were 28.4% and 14.2% respectively. The drug controlled releasing behaviors of the carriers were compared in different pH media.
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