期刊
PRION
卷 10, 期 1, 页码 83-91出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19336896.2015.1118603
关键词
CJD; chronic wasting disease; prion; neurodegeneration; amyloid; zoonotic
资金
- NIH [NS069566, NS076896, 1 K01 0D019919-01]
Prions cause fatal neurodegenerative diseases in humans and animals and can be transmitted zoonotically. Chronic wasting disease (CWD) is a highly transmissible prion disease of wild deer and elk that affects cervids over extensive regions of the United States and Canada. The risk of cross-species CWD transmission has been experimentally evaluated in a wide array of mammals, including non-human primates and mouse models expressing human cellular prion protein. Here we review the determinants of cross-species CWD transmission, and propose a model that may explain a structural barrier for CWD transmission to humans.
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