期刊
CHINESE CHEMICAL LETTERS
卷 26, 期 5, 页码 610-612出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2015.01.024
关键词
Mangrove-derived fungus; Penicillium brocae; Secondary metabolites; Pyranonigrin F; Antibacterial activity
资金
- National Natural Science Foundation of China [31270403]
- Ministry of Science and Technology of China [2010CB833802]
A new polyoxygenated dihydropyrano[2,3-c]pyrrole-4,5-dione derivative, pyranonigrin F (1), together with a related known compound, pyranonigrin A (2), were isolated and identified from Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these metabolites were determined based on comprehensive spectral interpretation and the absolute configuration of compound 1 was established by X-ray crystallographic analysis. Compounds 1 and 2 showed potent activity against a broad spectrum of human-, aqua-, and plant-pathogens. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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