Canagliflozin provides greater attainment of both HbA1c and body weight reduction versus sitagliptin in patients with type 2 diabetes

Objectives: To evaluate the proportion of patients with type 2 diabetes mellitus (T2DM) achieving reductions in both glycated hemoglobin (HbA1c) and body weight with canagliflozin, a sodium glucose co-transporter 2 inhibitor, versus sitagliptin over 52 weeks.Methods: Data were pooled from two, randomized, Phase 3 studies of canagliflozin 100 and 300mg versus sitagliptin 100mg as add-on to metformin, and canagliflozin 300mg versus sitagliptin 100mg as add-on to metformin plus sulfonylurea (N=1856). The composite end points of change from baseline in both HbA1c <0% and body weight <0kg, and attainment of HbA1c <7.0% and body weight reduction 5% at Week 52 were evaluated. Safety was assessed based on adverse event reports.Results: Canagliflozin provided reductions in HbA1c and body weight over 52 weeks versus sitagliptin. A greater proportion of patients had both HbA1c and body weight reductions with canagliflozin 100 and 300mg versus sitagliptin 100mg (67.7%, 72.6%, and 44.1%, respectively). Among patients with HbA1c and body weight reductions, more patients achieved the composite end point of HbA1c <7.0% and body weight reduction 5% with canagliflozin 100 and 300mg versus sitagliptin 100mg (18.9%, 18.3%, and 5.7%, respectively). Canagliflozin was generally well tolerated.Conclusions: A greater proportion of patients with T2DM achieved reductions in both HbA1c and body weight, and more patients with HbA1c and body weight reductions achieved HbA1c <7.0% and body weight reduction 5% with canagliflozin versus sitagliptin over 52 weeks.Clinical trial registration: www.ClinicalTrials.gov identifiers are NCT01106677; NCT01137812.