期刊
POLYMER SCIENCE SERIES A
卷 58, 期 2, 页码 154-166出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S0965545X16020048
关键词
-
资金
- Department of Science and Technology, India through the DST Fast Track Young Scientist Scheme [SR/FT/CS-76/2010]
pH-Responsive hydrogels comprised of chitosan and poly(vinyl alcohol) were explored for the controlled delivery of diclofenac sodium (DS) to the intestine. To regulate the drug delivery, preformed solid inclusion complex of DS with -cyclodextrin (-CD) was added into the hydrogels. Negligible drug release was observed in the simulated gastric fluid and sustained release in the intestinal fluid. The preliminary kinetics revealed that the drug release follows anomalous transport mechanism which is influenced by the presence of -CD. The pH-specific release behavior of these hydrogels suggests them to be ideal candidates for oral controlled delivery of DS to the intestine.
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