期刊
POLYMER CHEMISTRY
卷 7, 期 31, 页码 4998-5003出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6py00532b
关键词
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资金
- National Sciences and Engineering Research Council (NSERC)
- Qatar National Research Fund (QNRF) [NPRP 5 - 1505 - 1 - 250]
- Canadian Institutes of Health Research (CIHR)
- NSERC
Perfluorocarbons (PFCs) are a promising class of molecules for medical applications: they are detectable through F-19 nuclear magnetic resonance (NMR) and they assemble separately from water or lipophilic phases, thus bringing unique supramolecular interactions into nanostructures. We report the ready insertion of PFCs into nucleic acids, as well as non-natural polymers in a sequence-defined fashion. This is achieved via an automated and efficient synthetic pathway using phosphoramidite chemistry. Modulating the PFC tail length of DNA-Teflon block copolymers resulted in micelles that are almost monodisperse, have a low critical micelle concentration (CMC), are traceable by 19F NMR and are responsive to external stimuli. Strong fluorine-fluorine interactions in DNA duplexes allowed remarkable melting temperature increases and provided nuclease resistance. Finally, PFC insertion into siRNA was achieved, and the conjugates were efficient for gene silencing, outlining that these modifications are highly suitable for oligonucleotide therapeutics and bioimaging tools.
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