Antibacterial and antitumor activities of 3-amino-phenyl-4(3H)-quinazolinone/polypyrrole chitosan core shell nanoparticles

3-Amino-2-phenyl-4(3H)-quinazolinone (I) was prepared and loaded on polypyrrole chitosan (PPC) core shell nanoparticles (PPCI). The formation of core shell PPC nanoparticles were observed by transmission electron microscopy (TEM). The interaction between I and the synthesized PPC core shell nanoparticle was studied by Fourier transform infrared (FT-IR) spectroscopy. The average particle size of the PPC was 13 and 33 nm after loading I as determined by Scherer equation from X-ray diffraction (XRD) analysis. The synthesized PPCI exhibited antibacterial activity against gram negative as well as gram positive bacteria. In addition, the amount of loaded quinazolinone was calculated by thermal gravimetric analysis (TGA). The released amount of quinazolinone in different pH (2, 7.4) media and the mechanism of release by applying different model equations were studied. Moreover, the in vitro effect of the nanoparticles on Erlich ascites carcinoma (EAC) cells was enhanced after loading I.