期刊
POLYHEDRON
卷 117, 期 -, 页码 35-47出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2016.05.031
关键词
Biological activity; Organotin carboxylates; Structural determination; Drum-like structure; Sn-119 NMR
资金
- CNPq - Brazil
- CAPES - Brazil
- FAPEMIG - Brazil
The reactions of SnR2Cl2 (R = Me, Bu or Ph) with sodium 4-phenylbutyrate, NaO2C(CH2)(3)Ph (NaOPhb), yielded three organotin carboxylates, namely [{(Me2SnOPhb)(2)O}(2)] (1), [Bu2Sn(OPhb)(2)] (2) and [{PhSn(O)OPhb}(6)] (3). Complexes (1) and (2) have been spectroscopically authenticated by FT-IR, Sn-119 Mossbauer, and H-1, C-13{H-1} and Sn-119{H-1} NMR techniques. In addition, the crystallographic structures of (1)-(3) have been determined by X-ray diffraction measurements. Complex (1) displays two signals in the solution Sn-119 NMR spectrum corresponding to the exo (delta -176.3) and endocyclic (delta -188.4) SnMe2 moieties, whereas (2) exhibits only one Sn-119 resonance (delta -148.1). The crystallographic characterization of (1) confirms the centrosymmetric tetranuclear stannoxane structure and the existence of the exo and endocyclic SnMe2 moieties in the both distorted trigonal bipyramidal and octahedral environment, respectively. Complex (2) crystallises as a monomer in which the Sn(IV) cation lies at the centre of a distorted octahedron. The bonding scheme in (3) outlines a hexanuclear drum-like structure comprising two six-membered (-Sn-O-)(3) stannoxane rings. The supramolecular arrangements of (1)-(3) result from noncovalent interactions, namely Sn center dot center dot center dot O (1) and (2), C-H center dot center dot center dot pi (1), and C-H center dot center dot center dot O (1)-(3). Finally, antifungal activities of all organotin derivatives have been screened against Candida albicans (ATCC 18804), Candida tropicalis (ATCC 750), Candida glabrata (ATCC 90030), Candida parapsilosis (ATCC 22019), Candida lusitaniae (CBS 6936), and Candida dubliniensis (clinical isolate 28). Complex (2) exhibited the best biocide activity amongst the three organotin products. (C) 2016 Elsevier Ltd. All rights reserved.
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