期刊
POLYHEDRON
卷 117, 期 -, 页码 172-183出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.poly.2016.05.050
关键词
Nickel(II) complexes; Tolfenamic acid; Antioxidant activity; Interaction with albumins; Interaction with CT DNA
资金
- European Social Fund (ESF)
- Greek national funds (National Strategic Reference Framework, NSRF): Archimides III
- EU COST Action: Functional metal complexes that bind to biomolecules [CM1105]
The reaction of NiCl2 center dot 6H(2)0 with the non-steroidal anti-inflammatory drug tolfenamic acid (Htolf) in the absence or presence of a nitrogen-donor heterocyclic ligand such as 2,2'-bipyridine (bipy), 1,10-phenanthroline (phen), 2,2'-bipyridylamine (bipyam), 2,2'-dipyridylketone oxime (Hpko) and pyridine (py) led to the formation of six novel Ni(II) mononuclear complexes. The complexes were characterized by physicochemical and spectroscopic techniques and the crystal structures of complexes [Ni(tolf-O)(2)(bipy)(MeOH)(2)], 2 and [Ni(tolf-O)(2)(Hpko-N,N')(2)], 5 were determined by X-ray crystallography. The in vitro investigation of the ability of the complexes to scavenge 1,1-diphenyl-picrylhydrazyl, 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) and hydroxyl radicals and to inhibit soybean lipoxygenase revealed their potential antioxidant activity. The interaction of the complexes to calf-thymus DNA was monitored by diverse techniques (UV spectroscopy, cyclic voltammetry, viscosity measurements) revealing intercalation as the most possible mode of binding. Competitive studies of the complexes with ethidium bromide were monitored by fluorescence emission spectroscopy. The interaction of the complexes with serum albumins was studied by fluorescence emission spectroscopy and the binding constants of the compounds to the albumins were calculated. (C) 2016 Elsevier Ltd. All rights reserved.
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