期刊
PLOS ONE
卷 11, 期 9, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0161627
关键词
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资金
- Shenzhen Science Technology Research & Development Fund from Shenzhen Science Technology and Innovation Commission [JCYJ20140416141331514, JCYJ20140411150159429, JCYJ20140415151845360, JCYJ20130401114111453]
- Longgang District Science Fundamental Research fund from Longgang District Science Technology and Innovation Commission of Shenzhen [201406063001021]
- Shanghai Municipal Commission of Health and Family Planning [2013ZYJB0015]
- Science and Technology Commission of Shanghai Municipal [14411950402]
- Shenzhen Imuno Biotech Co., Ltd [20150308]
Early colonization of gut microbiota in human gut is a complex process. It remains unclear when gut microbiota colonization occurs and how it proceeds. In order to study gut microbiota composition in human early life, the present study recruited 10 healthy pairs of twins, including five monozygotic (MZ) and five dizygotic (DZ) twin pairs, whose age ranged from 0 to 6 years old. 20 fecal samples from these twins were processed by shotgun metagenomic sequencing, and their averaged data outputs were generated as 2G per sample. We used MEGAN5 to perform taxonomic and functional annotation of the metagenomic data, and systematically analyzed those 20 samples, including Jaccard index similarity, principle component, clustering, and correlation analyses. Our findings indicated that within our study group: 1) MZ-twins share more microbes than DZ twins or non-twin pairs, 2) gut microbiota distribution is relatively stable at metabolic pathways level, 3) age represents the strongest factor that can account for variation in gut microbiota, and 4) a clear metabolic pathway shift can be observed, which speculatively occurs around the age of 1 year old. This research will serve as a base for future studies of gut microbiota-related disease research.
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