期刊
CHILD NEUROPSYCHOLOGY
卷 23, 期 2, 页码 208-227出版社
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/09297049.2015.1108395
关键词
Cancer; brain tumor; attention; speed; memory
资金
- Dutch Cancer Society KWF Kankerbestrijding [UVA 2008-4013]
- Dutch Children Cancer Free Foundation, KiKa [SKK-PRISMA]
With more children surviving a brain tumor, insight into the late effects of the disease and treatment is of high importance. This study focused on profiling the neurocognitive functions that might be affected after treatment for a pediatric brain tumor, using a broad battery of computerized tests. Predictors that may influence neurocognitive functioning were also investigated. A total of 82 pediatric brain tumor survivors (PBTSs) aged 8-18years (M=13.85, SD=3.15, 49% males) with parent-reported neurocognitive complaints were compared to a control group of 43 siblings (age M=14.27, SD=2.44, 40% males) using linear mixed models. Neurocognitive performance was assessed using measures of attention, processing speed, memory, executive functioning, visuomotor integration (VMI), and intelligence. Tumor type, treatment, tumor location, hydrocephalus, gender, age at diagnosis, and time since diagnosis were entered into regression analyzes as predictors for neurocognitive functioning. The PBTSs showed slower processing speeds and lower intelligence (range effect sizes .71-.82, p<.001), as well as deficits in executive attention, short-term memory, executive functioning, and VMI (range effect sizes .40-.57, p<.05). Older age at assessment was associated with better neurocognitive functioning (B=.450, p<.001) and younger age at diagnosis was associated with lower intelligence (B=.328, p<.05). Medical risk factors, e.g., hydrocephalus, did not show an association with neurocognitive functioning. Late effects in PBTSs include a broad range of neurocognitive deficits. The results suggest that even PBTSs that were traditionally viewed as low risk for neurocognitive problems (e.g., surgery only, no hydrocephalus) may suffer from decreased neurocognitive functioning.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据