期刊
PLOS ONE
卷 11, 期 5, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0155681
关键词
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资金
- National Institutes of Health [EB012597, EB017876]
- National Research Foundation of Korea (NRF) [2014R1A1A2A16054777, 2010-0018294]
- Korea Health Industry Development Institute (KHIDI) [HI14C3228]
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1332681] Funding Source: National Science Foundation
- National Research Foundation of Korea [2014R1A1A2A16054777] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson's ratio v(xy) (NPR). NPR constructs have the unique ability to expand transversely when pulled axially, thereby resulting in a highly-compliant tubular construct. In this work, we used projection stereolithography to 3D-print a planar NPR sheet composed of photosensitive poly(ethylene) glycol diacrylate biomaterial. We used a step-lithography exposure and a stitch process to scale up the projection printing process, and used the cut-missing rib unit design to develop a centimeter-scale NPR sheet, which was rolled up to form a tubular construct. The constructs had Poisson's ratios of -0.6 <= -v(xy) <= -0.1. The NPR construct also supports higher cellular adhesion than does the construct that has positive v(xy). Our NPR design offers a significant advance in the development of highly-compliant vascular grafts.
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