期刊
PLOS ONE
卷 11, 期 1, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0146402
关键词
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资金
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA01040407]
- National Natural Science Foundation of China [91019024, 31100558, 91131002]
- National Basic Research Program of China (973 Program) [2012CB518302, 2013CB911001]
- National Excellent Youth Science Foundation of China [31222030]
- Shanghai Rising-Star Program [12QA1400300]
- China Ministry of Education Scientific Research Major Project [311016, 113022A]
- MOE University Doctoral Research Supervisor's Funds [20120071110021]
- Shanghai Professional Development Funding [2010001]
DNA methylation plays an important role for mammalian development. However, it is unclear whether the DNA methylation pattern is evolutionarily conserved. The Y chromosome serves as a powerful tool for the study of human evolution because it is transferred between males. In this study, based on deep-rooted pedigrees and the latest Y chromosome phylogenetic tree, we performed epigenetic pattern analysis of the Y chromosome from 72 donors. By comparing their respective DNA methylation level, we found that the DNA methylation pattern on the Y chromosome was stable among family members and haplogroups. Interestingly, two haplogroup-specific methylation sites were found, which were both genotype-dependent. Moreover, the African and Asian samples also had similar DNA methylation pattern with a remote divergence time. Our findings indicated that the DNA methylation pattern on the Y chromosome was conservative during human male history.
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