期刊
PLOS ONE
卷 11, 期 4, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0153398
关键词
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资金
- National Health and Medical Research Council of Australia (NHMRC Program) [APP566940]
- Centre of Research Excellence grant [APP1057608, APP1000986]
- Senior Principal Research Fellowship [1003960]
- Dementia Research Development Fellowship [1103311]
- Australian Research Council Research Fellowship [FT100100918]
- Heart Foundation Postdoctoral Fellowship [PH 12B 7054]
- Victorian Government's OIS Program
- Australian Federal Government (Australian Postgraduate Award Scholarship)
- Victorian Government's OIS Programme
- National Health and Medical Research Council (NHMRC) [233200]
- Australian Government Department of Health and Ageing
- Abbott Australasia Pty Ltd
- Alphapharm Pty Ltd
- AstraZeneca, Bristol-Myers Squibb
- City Health Centre-Diabetes Service-Canberra
- Department of Health and Community Services-Northern Territory
- Department of Health and Human ServicesTasmania
- Department of Health-New South Wales
- Department of Health-Western Australia
- Department of Health-South Australia
- Department of Human Services-Victoria
- Diabetes Australia
- Diabetes Australia Northern Territory
- Eli Lilly Australia
- Estate of the Late Edward Wilson
- GlaxoSmithKline
- Jack Brockhoff Foundation
- Janssen-Cilag
- Kidney Health Australia
- Marian FH Flack Trust
- Menzies Research Institute
- Merck Sharp Dohme
- Novartis Pharmaceuticals
- Novo Nordisk Pharmaceuticals
- Pfizer Pty Ltd
- Pratt Foundation
- Queensland Health
- Roche Diagnostics Australia
- Royal Prince Alfred Hospital, Sydney
- Sanofi Aventis
- Sanofi Synthelabo
The purpose of this study was to investigate the cross-sectional associations of monitorderived measures of sedentary time and physical activity with performance-based physical function in healthy Australian adults. Data from 602 participants (mean age 58.1 +/- 10.0 years; 58% female) from the 2011/12 wave of the Australian Diabetes, Obesity and Lifestyle (AusDiab3) study were analyzed. The thigh-worn activPAL3 T monitor (7-days continuous wear) was used to derive time during waking hours spent: sitting/reclining; standing; and, stepping (overall, and separately as light [<3 METs] and moderate-to-vigorous physical activity [ MVPA; >= 3 METs]), and number of sit-stand transitions. Associations of these (in hours/day, or 15 transitions/ day) with physical function measures (8ft Timed Up and Go [ TUG-8; log-transformed seconds] and Knee Extensor Strength [ KES; kg]) were tested via linear regression, adjusting for confounders. Interactions by sex and age-category (< 45; 45-54; 55-64; >= 65 years) were tested. In all participants, KES was significantly (p<0.05) associated with stepping and MVPA stepping only; none of the activity measures were associated with TUG-8. However, subgroup analysis revealed that in older adults (>= 65 years), TUG-8 was associated with stepping and MVPA stepping (both p<0.05). All associations with sitting time, standing, sit-stand transition and sex interactions were not statistically significant. In summary, sitting time was not significantly associated with impaired muscle strength or gait/mobility in Australian adults aged 36-80 years, but light-to moderate activity (stepping) was positively associated with muscle strength, and gait/mobility in older adults aged >= 65 years. The direction of causation is not known and remains important to investigate considering the high prevalence of both poor function and limited activity in older age.
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