期刊
PLOS ONE
卷 11, 期 5, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0154945
关键词
-
资金
- Societe Francaise de Radiologie
Background and Purpose Approximately 30% of strokes are cryptogenic despite an exhaustive in-hospital work-up. Analysis of clot composition following endovascular treatment could provide insight into stroke etiology. T-cells already have been shown to be a major component of vulnerable atherosclerotic carotid lesions. We therefore hypothesize that T-cell content in intracranial thrombi may also be a biomarker of atherothrombotic origin. Materials and Methods We histopathologically investigated 54 consecutive thrombi retrieved after mechanical thrombectomy in acute stroke patients. First, thrombi were classified as fibrin-dominant, erythrocyte-dominant or mixed pattern. We then performed quantitative analysis of CD3+ cells on immunohistochemically-stained thrombi and compared T-cell content between atherothrombotic, cardioembolism and other causes stroke subtypes. Results Fourteen (26%) thrombi were defined as fibrin-dominant, 15 (28%) as erythrocyte-dominant, 25 (46%) as mixed. The stroke cause was defined as atherothrombotic in 10 (18.5%), cardioembolism in 25 (46.3%), and other causes in 19 (35.2%). Number of T-cells was significantly higher in thrombi from the atherothrombotic group (53.60 +/- 28.78) than in the other causes (21.77 +/- 18.31; p < 0.0005) or the cardioembolism group (20.08 +/- 15.66; p < 0.0003). Conclusions The CD3+ T-cell count in intracranial thrombi was significantly higher in atherothrombotic origin strokes compared to all other causes. Thrombi with high content of CD3+ cells are more likely to originate from an atherosclerotic plaque.
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