期刊
PLOS ONE
卷 11, 期 3, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0150226
关键词
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资金
- Region Champagne-Ardenne
- Fond Europeen de Developpement Regional FEDER-CPER
- Ligue contre le Cancer, Conference de Coordination InterRegionale du Grand Est [CCIR-GE-30036506-UMR7369]
- Healthy Ageing Research Centre - HARC project under EU
- National Institutes of Health, USA [NIH-EY11654]
- National Science Centre, Poland - MAESTRO grant [UMO-/2011/02/A/NZ3/00068]
Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in B16F1 but not in HT-29 cells. In Snail-B16F1 cells, lumican inhibits migration, growth, and melanoma primary tumor development. A lumican-based strategy targeting Snail-induced MMP-14 activity might be useful for melanoma treatment.
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