期刊
PLATELETS
卷 27, 期 6, 页码 505-511出版社
TAYLOR & FRANCIS INC
DOI: 10.3109/09537104.2016.1171304
关键词
GPIb; platelet clearance; Ashwell-Morell receptor; sialic acid
资金
- National Institutes of Health (NIH) [HL107146, HL089224, HL082808, HL123984]
- Brigham Research Institute
- American Society of Hematology
Platelet numbers are intricately regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. The growth factor thrombopoietin (TPO) drives platelet biogenesis by inducing megakaryocyte production. A recent study in mice identified a feedback mechanism by which clearance of aged, desialylated platelets stimulates TPO synthesis by hepatocytes. This new finding generated renewed interest in platelet clearance mechanisms. Here, different established and emerging mechanisms of platelet senescence and clearance will be reviewed with specific emphasis on the role of posttranslational modifications.
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