期刊
PLANTA MEDICA
卷 83, 期 3-4, 页码 306-311出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0042-115646
关键词
Plectranthus spp.; Aeollanthus rydingianus; Lamiaceae; diterpenoids; antitrypanosomal activity; intracellular amastigotes
资金
- MINECO, Spain [CTQ2012-38219-C03-01, CTQ2015-64049-C3-1-R]
- Fundacao para a Ciencia e Tecnologia (FCT) [UID/MULTI/00612/2013]
Twenty-seven diterpenes, including abietanes, labdanes, abeoabietanes, halimanes, and pimaranes, have been evaluated against epimastigote and intracellular amastigote forms of Trypanosoma cruzi and also against LC5 and NCTC cell lines. Royleanones (3, 4, and 5) and a further abietane (12), obtained by purification of Plectranthus spp. extracts, were the most active compounds on epimastigotes, showing IC50 values similar (1.73 mu g/mL, 12) or even lower (0.39, 0.99, and 1.20 mu g/mL, 3, 4, and 5 respectively) than the positive control nifurtimox (2.3 mu g/mL). On intracellular amastigotes, abietanes 3, 4, and 5 showed a significant activity with IC50 values of 0.83, < 0.31, and 0.62 mu g/mL, respectively, but were less potent than the positive control nifurtimox (IC50 < 0.16 mu g/mL). Compounds 3, 4, and 5 were not cytotoxic to LC5 and NCTC 929 cells at 1 mu g/mL.
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