期刊
PLANT SCIENCE
卷 245, 期 -, 页码 128-134出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.plantsci.2016.02.002
关键词
Quantitative genetics; QTL; Gene balance hypothesis; Interactome; Dosage effect; Inverse effect; Genetic load; Epistasis; Missing heritability; Macromolecular complexes; Dominance; Additive inheritance
资金
- University of Missouri Life Sciences Fellowship
- University Paris VII
- Centre National de la Recherche Scientifique
- l'Agence Nationale de la Recherche (Iceberg Project)
- Ligue Nationale contre le Cancer
- Fondation pour la Recherche Medicale
While most mutations are recessive, variants that affect quantitative traits are largely semi-dominant in their action making hybrids between divergent genotypes intermediate. In parallel, changes in chromosomal dosage (aneuploidy) for multiple regions of the genome modulate quantitative characters. We have previously argued that these observations are a reflection of a common process, originating from the more or less subtle effects of changes in dosage on the action of multi-subunit regulatory machineries. Kinetic analyses that vary the amount of one subunit of a complex while holding others constant do not always predict a linear response for the production of the whole. Indeed, in many instances, strong non-linear effects are expected. Here, we advocate that these kinetic observations and predictions should be incorporated into quantitative genetics thought. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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