期刊
PLANT CELL
卷 28, 期 12, 页码 2937-2951出版社
AMER SOC PLANT BIOLOGISTS
DOI: 10.1105/tpc.16.00656
关键词
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资金
- Swiss National Science Foundation Early PostDoc Mobility grant
- Netherlands Genomics Initiative Grant [050-10-108]
- Netherlands Organisation for Scientific Research (NWO)-Horizon Grant [050-71-054]
- ALW-NWO European Research Area Network Plant Genomics grant
- EMBO long-term fellowship
- Japan Society for the Promotion of Science [19060011]
- European Research Council Advanced Investigator Fellowship
- NWO-SPINOZA award
- Netherlands Institute of Regenerative Medicine Consortium grant
- Centre for BioSystems Genomics Grant [AA5-UU]
- Kempestiftelserna
- Swedish Governmental Agency for Innovation Systems (VINNOVA)
- Swedish Research Council (VR)
- Ministry of Education, Youth, and Sports of the Czech Republic [LO1204]
- Academy of Finland
- University of Helsinki
- Human Frontier Science Program fellowship [LT00558/2006-L]
- Graduate School Experimental Plant Sciences
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1257805] Funding Source: National Science Foundation
- Grants-in-Aid for Scientific Research [19060011] Funding Source: KAKEN
Organ formation in animals and plants relies on precise control of cell state transitions to turn stem cell daughters into fully differentiated cells. In plants, cells cannot rearrange due to shared cell walls. Thus, differentiation progression and the accompanying cell expansion must be tightly coordinated across tissues. PLETHORA (PLT) transcription factor gradients are unique in their ability to guide the progression of cell differentiation at different positions in the growing Arabidopsis thaliana root, which contrasts with well-described transcription factor gradients in animals specifying distinct cell fates within an essentially static context. To understand the output of the PLT gradient, we studied the gene set transcriptionally controlled by PLTs. Our work reveals how the PLT gradient can regulate cell state by region-specific induction of cell proliferation genes and repression of differentiation. Moreover, PLT targets include major patterning genes and autoregulatory feedback components, enforcing their role as master regulators of organ development.
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