期刊
PIGMENT CELL & MELANOMA RESEARCH
卷 29, 期 6, 页码 607-618出版社
WILEY
DOI: 10.1111/pcmr.12511
关键词
skin colour; skin type; photobiology; melanin; ultraviolet radiation
资金
- Walgreens Boots Alliance, UK
- National Institute for Health Research (NIHR) Clinical Research Facility at Guy's & St Thomas' NHS Foundation Trust
- NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London
- King's College London
Terrestrial solar ultraviolet radiation (UVR) exerts both beneficial and adverse effects on human skin. Epidemiological studies show a lower incidence of skin cancer in people with pigmented skins compared to fair skins. This is attributed to photoprotection by epidermal melanin, as is the poorer vitamin D status of those with darker skins. We summarize a wide range of photobiological responses across different skin colours including DNA damage and immunosuppression. Some studies show the generally modest photoprotective properties of melanin, but others show little or no effect. DNA photodamage initiates non-melanoma skin cancer and is reduced by a factor of about 3 in pigmented skin compared with white skin. This suggests that if such a modest reduction in DNA damage can result in the significantly lower skin cancer incidence in black skin, the use of sunscreen protection might be extremely beneficial for susceptible population. Many contradictory results may be explained by protocol differences, including differences in UVR spectra and exposure protocols. We recommend that skin type comparisons be done with solar-simulated radiation and standard erythema doses or physical doses (J/m(2)) rather than those based solely on clinical endpoints such as minimal erythema dose (MED).
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