期刊
PHYTOTHERAPY RESEARCH
卷 30, 期 11, 页码 1765-1774出版社
WILEY
DOI: 10.1002/ptr.5694
关键词
oroxylin A; pharmacological activity; anti-cancer; review
资金
- National Science and Technology Major Project [2012ZX09304-001, 2013ZX09103-001-007]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1193]
- State Key Laboratory of Natural Medicines, China Pharmaceutical University [G140042]
- National Natural Science Foundation of China [81373449, 81473231]
- Science Foundation for Distinguished Young Scholars of Jiangsu Province [BK20150028]
Oroxylin A is one of the main active components extracted from Scutellariae radix. It has been proved that oroxylin A possesses a broad spectrum of pharmacological functions, including anti-cancer, antiinflammation, neuroprotective, anti-coagulation and so on. The pharmacological activity of oroxylin A has been studied in vitro and on animal models, which reflected its promising potency in disease treatment. This review aims to recapitulate the pharmacological function and the molecular mechanisms of oroxylin A, as well as its sources, extraction, synthesis and toxicity study. These data confirmed the therapeutic potential of oroxylin A and provided reference for further development. Copyright (C) 2016 John Wiley & Sons, Ltd.
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