期刊
PHYTOTHERAPY RESEARCH
卷 30, 期 10, 页码 1634-1640出版社
WILEY
DOI: 10.1002/ptr.5664
关键词
Rubus occidentalis; black raspberry; metabolic syndrome; prediabetes; atherosclerosis
资金
- Gochang Regional Research Institute, Ministry of Trade, Industry and Energy, South Korea
Rubus occidentalis (RO) has beneficial effects on glucose and lipid profiles in vitro. The aim of the study was to investigate RO extract effect on metabolic parameters in prediabetic patients, adopting a 12-week, randomized, double-blind, placebo-controlled trial. Forty-four patients (age 59.0 +/- 8.2years, 70.5% females, HbA1c 5.8 +/- 0.4%) were divided into placebo (n=13), low-dose RO extract (LRE; n=14), or high-dose RO extract (HRE; n=17) groups. Either 900 or 1800mg per day of RO extract was administered orally. Area under the curve for glucose obtained 2h after a 75-g oral glucose tolerance test was significantly decreased in the HRE group, compared with the placebo group (-28.1 +/- 42.4 vs. +13.4 +/- 52.6mg/dL, p<0.05). Homoeostasis model assessment-B was increased (+17.11 +/- 10.69, +5.24 +/- 4.10, and +0.86 +/- 6.01 in HRE, LRE, and placebo, respectively, p<0.05). Serum levels of monocyte chemoattractant protein-1 and oxidized low-density lipoprotein were significantly decreased by treatment in a dose-dependent manner (monocyte chemoattractant protein-1: -35.0 +/- 21.2, +8.4 +/- 18.1, and +24.2 +/- 14.5; oxidized low-density lipoprotein: -19.7 +/- 8.5, -13.1 +/- 7.2, and -2.2 +/- 11.0 in the HRE, LRE, and placebo, respectively, p<0.05). The results support the beneficial effects of RO extract on the control of glycemia and vascular inflammation in prediabetic patients. (ClinicalTrials.gov: NCT01964703). Copyright (c) 2016 John Wiley & Sons, Ltd.
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