期刊
PHYTOCHEMISTRY LETTERS
卷 17, 期 -, 页码 288-292出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2016.08.012
关键词
Marine sponge; Spongia sp.; Sesquiterpene aminoquinone; 4,9-Friedodrimane; Antibacterial activities; Smenospongine
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Kobayashi International Scholarship Foundation
- Grants-in-Aid for Scientific Research [26460140, 15H05138] Funding Source: KAKEN
Two new sesquiterpene aminoquinones, langcoquinones A (1) and B (2), together with seven known meroterpenoids (3-9), were isolated from the marine sponge Spongia sp. collected in Vietnam. Their structures were determined on the basis of spectroscopic analyses and comparisons with published data. The antibacterial activities of the isolated compounds (1-9) were investigated against four bacterial strains. Among these, the new sesquiterpene aminoquinones (1 and 2) and the known related compounds (3, 5, 6, 8, and 9) exhibited significant antibacterial activities against Staphylococcus aureus and Bacillus subtilis, with MICs ranging from 6.25 to 12.5 mu M. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.
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