期刊
PHYTOCHEMISTRY LETTERS
卷 17, 期 -, 页码 28-35出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.phytol.2016.06.006
关键词
Aspergillus felis; Alkaloidal metabolites; Perhydroisoindol; Paracoccidioides brasiliensis; Antifungal activity
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Program of Technological Development in Tools for Health-PDTIS-FIOCRUZ analytical platform (RPT13A)
In this study, the fungus Aspergillus felis (strain UFMGCB 8030) was isolated from rocks in the Atacama Desert, Chile. Its CH2Cl2 extract exhibited antifungal activity (MIC of 1.9 mu g/mL) against Paracoccidioides brasiliensis (Pb18), which is the etiological agent for paracoccidioidomycosis. The crude extract was purified, and a new cytochalasin derivative, cytochalasin Z(15E) (1), and one ardeemin derivative, 5-N-acetyl-8-beta-isopropyl-ardeemin (4), in addition to five known secondary metabolites, rosellichalasin (2), cytochalasin E(3), gancidin (5), pseurotin A1 (6), and 2,4-dihydroxyacetophenone (7), were isolated. The structures of these compounds were confirmed by 1D and 2D NMR spectroscopy and HR-ESI-MS. Cytochalasin E was the most active compound with MIC an value of 3.6 mu M, while the other isolated compounds exhibited weak antifungal activities (MIC values > 100.0 mu M). (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据