期刊
PHYTOCHEMISTRY LETTERS
卷 17, 期 -, 页码 177-180出版社
ELSEVIER
DOI: 10.1016/j.phytol.2016.07.020
关键词
Valeriana jatamansi; Secoiridoid glycoside; Sesquiterpenoid glycoside; Neuroprotective activity
资金
- National Science Foundation for Fostering Talents in Basic Research of the National Natural Science Foundation of China fund [J13100340-11]
- key fund project for Education Department of Sichuan [15ZA0093]
- youth science and technology innovative research team fund project of Sichuan [2016TD0006]
- project for administration of Traditional Chinese Medicine [2016Q049]
A new secoiridoid glycoside, isopatrinioside (1) and a new sesquiterpenoid glycoside, valeriananoid F (2), together with nine known compounds, were isolated from the roots of Valeriana jatamansi. Their structures were elucidated on the basis of spectroscopic analysis. Compound 1 was an unusual monocyclic iridoid glycoside ring-opened between C-1 and C-2 produced by the cleavage of the pyran ring. Of the eleven isolates, compounds 1 and 4 exhibited moderate neuroprotective effects against CoCl2-induced neuronal cell death in PC12 cells. (C) 2016 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.
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