Two new phragmalin-type limonoids from stems of Chukrasia tabularis

Phytochemical investigation on the stems of Chukrasia tabularis A. Juss led to the isolation of two new phragmalin-type limonoids and three known ones. The structures of the new compounds were elucidated as Chuklarisin A (1) and Chuklarisin B (2) by spectroscopic techniques (IR, HRESIMS, 1D and 2D NMR) and comparing with published data. All the compounds were evaluated for alpha-glucosidase inhibitory activity in vitro. Compounds 2, 3, and 4 exhibited inhibitory activity against alpha-glucosidase with IC50 values of 0.96, 0.03, and 0.53 mM, respectively (acarbose as positive control, IC50 0.95 mM). (C) 2016 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.