期刊
PHYTOCHEMISTRY LETTERS
卷 15, 期 -, 页码 16-20出版社
ELSEVIER
DOI: 10.1016/j.phytol.2015.11.002
关键词
Vernonia amygdalina; Asteraceae; C-29 steroid saponins; Anti-inflammatory
资金
- National Natural Sciences Foundation of China [8140032]
- Program for New Century Excellent Talents in University [NCET-2013-1035]
- Program for Changjiang Scholars and Innovative Research Team in University [PCSIRT-IRT1193]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Vernoamyosides A-D (1-4), four new Delta(7, 9(11)) stigmastane-type steroid saponins were isolated from the dried leaves of an African medicinal plant Vernonia amygdalina Delile (Asteraceae). Their structures were determined by a combination of spectroscopic analyses (HR-ESI-MS, 1D/2D NMR) and by chemical methods. These four new compounds possessed highly oxidized side chains (C-20-C-29), and formed complex ring systems in 2-4. The inhibitory effects on NO production in lipopolysaccharide-activated RAW264.7 macrophages of these new compounds were tested. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
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