期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 61, 期 23, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/61/23/L48
关键词
ultrasound; 4D ultrafast imaging; volumetric flow rate; 3D blood velocity vector
资金
- European Research Council under the European Union's Seventh Framework Programme (FP)/ERC Grant [311025]
- PSL* Research University [ANR-10-IDEX-0001-02]
We present herein 4D ultrafast ultrasound flow imaging, a novel ultrasound-based volumetric imaging technique for the quantitative mapping of blood flow. Complete volumetric blood flow distribution imaging was achieved through 2D tilted plane-wave insonification, 2D multi-angle cross-beam beamforming, and 3D vector Doppler velocity components estimation by least-squares fitting. 4D ultrafast ultrasound flow imaging was performed in large volumetric fields of view at very high volume rate (> 4000 volumes s(-1)) using a 1024-channel 4D ultrafast ultrasound scanner and a 2D matrix-array transducer. The precision of the technique was evaluated in vitro by using 3D velocity vector maps to estimate volumetric flow rates in a vessel phantom. Volumetric Flow rate errors of less than 5% were found when volumetric flow rates and peak velocities were respectively less than 360 ml min(-1) and 100 cm s(-1). The average volumetric flow rate error increased to 18.3% when volumetric flow rates and peak velocities were up to 490 ml min(-1) and 1.3 m s(-1), respectively. The in vivo feasibility of the technique was shown in the carotid arteries of two healthy volunteers. The 3D blood flow velocity distribution was assessed during one cardiac cycle in a full volume and it was used to quantify volumetric flow rates (375 +/- 57 ml min(-1) and 275 +/- 43 ml min(-1)). Finally, the formation of 3D vortices at the carotid artery bifurcation was imaged at high volume rates.
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