期刊
CHEMPHYSCHEM
卷 16, 期 16, 页码 3433-3437出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cphc.201500484
关键词
anti-HIV; catanionic surfactants; dendrimers; galactosylceramide; glycolipids
资金
- University Toulouse III
- CNRS
- European Community
The self-association properties of anti-HIV catanionic dendrimers as multivalent galactosylceramide (GalCer)-derived inhibitors are presented. The study was designed to elucidate the origin of the relatively high cytotoxicity values of these antiHIV catanionic dendrimers, which have previously been found to exhibit in vitro anti-HIV activity in the submicromolar range. The physicochemical properties of these catanionic dendrimers were studied to tentatively correlate the structural parameters with self-association and biological properties. We can conclude from this study that the absence of correlation between the hydrophobicity and the cytotoxicity of the catanionic systems could be explained by the partial segregation of the different partners of the catanionic entities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据