期刊
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
卷 18, 期 28, 页码 18687-18691出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cp03506j
关键词
-
资金
- US National Institutes of Health (NIH) [AR056657, AR052010]
Using H-1-based magic angle spinning solid-state NMR spectroscopy, we report an atomistic-level characterization of triglycerides in compact cortical bone. By suppressing contributions from immobile molecules present in bone, we show that a H-1-based constant-time uniform-sign cross-peak (CTUC) two-dimensional COSY-type experiment that correlates the chemical shifts of protons can selectively detect a mobile triglyceride layer as the main component of small lipid droplets embedded on the surface of collagen fibrils. High sensitivity and resolution afforded by this NMR approach could be potentially utilized to investigate the origin of triglycerides and their pathological roles associated with bone fractures, diseases, and aging.
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