期刊
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
卷 18, 期 18, 页码 12409-12413出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cp00589f
关键词
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资金
- Swiss National Science Foundation [310030_138146, PPOOP1_157547]
- Swiss National Science Foundation (SNF) [310030_138146] Funding Source: Swiss National Science Foundation (SNF)
[1-C-13]pyruvate is the most widely used hyperpolarized metabolic magnetic resonance imaging agent. Using a custom-built 7.0 T polarizer operating at 1.0 K and trityl radical-doped [1-C-13] pyruvic acid, unextrapolated solution-state C-13 polarization greater than 60% was measured after dissolution and rapid transfer to a spectrometer magnet, demonstrating the signal enhancement attainable using optimized hardware. Slower rates of polarization under these conditions can be largely overcome with higher radical concentrations.
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