期刊
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
卷 18, 期 25, 页码 16682-16689出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6cp02876d
关键词
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资金
- Deutsche Forschungsgemeinschaft [SPP1807, SCHN1280/4-1]
- excellence cluster The Hamburg Centre for Ultrafast Imaging - Structure, Dynamics and Control of Matter at the Atomic Scale of the Deutsche Forschungsgemeinschaft
- Alexander von Humboldt Foundation
Conformational flexibility is intrinsically related to the functionality of biomolecules. Elucidation of the potential energy surface is thus a necessary step towards understanding the mechanisms for molecular recognition such as docking of small organic molecules to larger macromolecular systems. In this work, we use broadband rotational spectroscopy in a molecular jet experiment to unravel the complex conformational space of citronellal. We observe fifteen conformations in the experimental conditions of the molecular jet, the highest number of conformers reported to date for a chiral molecule of this size using microwave spectroscopy. Studies of relative stability using different carrier gases in the supersonic expansion reveal conformational relaxation pathways that strongly favour ground-state structures with globular conformations. This study provides a blueprint of the complex conformational space of an important biosynthetic precursor and gives insights on the relation between its structure and biological functionality.
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