期刊
CHEMOSPHERE
卷 132, 期 -, 页码 172-178出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2015.03.006
关键词
Clarias batrachus; Pesticide; Vitamin C; Haematology; Biochemistry
The study was conducted to explore the modulatory effects of chlorpyrifos and protective role of vitamin C in tissues of Clarias batrachus. Treatments include El group (basal diet plus 1.65 mg L-1 CPF) and E-2 group (basal diet + 200 mg kg body weight vitamin C and 1.65 mg L-1 CPF) along with a control group of fishes (fed on basal diet only). After 1, 7, 15, and 30 d of treatment, fish tissues (brain, blood and liver) were used for the estimation of growth, biochemical and haematological parameters. The results of E-1 group indicated significantly lower weight gain and survival rate. Brain AChE activity was inhibited. The RBC, Hb, respiratory burst activity, total protein and HSI were also reduced whereas WBC count, plasma glucose and haematocrit were elevated. In contrast, liver glycogen content, lactate dehydrogenase, alkaline and acid phosphatase activities were inhibited and malate dehydrogenase, aspartate, alanine amino transferase were enhanced. The E2 group of fish exhibited significant improvement in growth, survival, haematological indices, brain AChE, liver glycogen and oxidative enzyme activity. The findings support that dietary vitamin C supplementation might be helpful in abrogation of chlorpyrifos toxicity and improves growth, survival, biochemical and haematological conditions in fishes. (C) 2015 Elsevier Ltd. All rights reserved.
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