期刊
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
卷 32, 期 9, 页码 1139-1144出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejmp.2016.08.018
关键词
Radio-guided-surgery; Brain tumors; beta-decays; Intraoperative imaging
Purpose: A radio-guided surgery technique with beta(-)-emitting radio-tracers was suggested to overcome the effect of the large penetration of gamma radiation. The feasibility studies in the case of brain tumors and abdominal neuro-endocrine tumors were based on simulations starting from PET images with several underlying assumptions. This paper reports, as proof-of-principle of this technique, an ex vivo test on a meningioma patient. This test allowed to validate the whole chain, from the evaluation of the SUV of the tumor, to the assumptions on the bio-distribution and the signal detection. Methods: A patient affected by meningioma was administered 300 MBq of Y-90-DOTATOC. Several samples extracted from the meningioma and the nearby Dura Mater were analyzed with a beta-probe designed specifically for this radio-guided surgery technique. The observed signals were compared both with the evaluation from the histology and with the Monte Carlo simulation. Results: we obtained a large signal on the bulk tumor (105 cps) and a significant signal on residuals of similar to 0.2 ml (28 cps). We also show that simulations predict correctly the observed yields and this allows us to estimate that the healthy tissues would return negligible signals (approximate to 1 cps). This test also demonstrated that the exposure of the medical staff is negligible and that among the biological wastes only urine has a significant activity. Conclusions: This proof-of-principle test on a patient assessed that the technique is feasible with negligible background to medical personnel and confirmed that the expectations obtained with Monte Carlo simulations starting from diagnostic PET images are correct. (C) 2016 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.
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