期刊
AAPS PHARMSCITECH
卷 17, 期 3, 页码 631-639出版社
SPRINGER
DOI: 10.1208/s12249-015-0376-z
关键词
Activation energy; Compound D; Niosomal gel; Topical anti-inflammatory; Zingiber cassumunar
资金
- Thailand Research Fund [MRG-WI53S026]
- T.C. Pharmachem Co. Ltd.
An extract of Zingiber cassumunar Roxb. (ZC) was encapsulated in niosomes of which a topical gel was formed. (E)-4-(3',4'-dimethoxyphenyl)but-3-en-1-ol or compound D detected by a gradient HPLC was employed as the marker and its degradation determined to follow zero-order kinetics. Niosomes significantly retarded thermal-accelerated decomposition of compound D in the gel (p<0.05) but did not change the activation energy of compound D. Niosomes enhanced in vitro permeation rate of compound D from the gel. Topical applications of ZC noisome gel gave a faster change in tail flick latency than piroxicam gel and hydrocortisone cream (p<0.05) while there were insignificant differences in antiinflammatory activity up to 6 h using croton oil-induced ear edema model in mice (p>0.05). Thus, encapsulation of ZC extract in niosomes enhanced chemical stability and skin permeation with comparable topical anti-inflammatory effects to steroid and NSAID.
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