期刊
CHEMOSPHERE
卷 119, 期 -, 页码 8-15出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2014.04.105
关键词
Antibiotics; Water; Multiclass; LC-MS/MS
A sensitive liquid-chromatography-electrospray tandem mass spectrometry multiclass method for determination of 45 veterinary compounds belonging to 9 different antibiotic groups, including amino-glicosides (4), beta-lactams (13), diaminopyrimidines (1), fluoroquinolones (10), lincosamides (1), macrolides (5), pleuromutilins (1), sulfonamides (6) and tetracyclines (4), in water from breeding animal watering supply system has been developed. Isolation of the analytes was carried out by solid phase extraction with heptafluorobutyric acid as an ion-pair agent on the Strata-X reversed phase cartridges. All analytes were determined simultaneously in one single run on a C18 column with gradient elution and short analysis time (13 min). Method was validated, average relative recoveries were in the range of 84.3-109.3% with satisfactory precision are repeatability for all compounds are in the range of 4.7-12.2%, within-laboratory reproducibility are in the range of 4.4-13.5% for. The limit of quantitation (LOQ) of the method was in the range of 0.02-10 mu g L-1, depending of analyte. The applicability of the method was tested by determining antimicrobial compounds in real water samples collected from water supply systems in breeding animal farms. The average antibiotics concentration in real water samples were, respectively, in the range of 0.14-1670 mu g L-1. (C) 2014 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据