期刊
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 371, 期 1705, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rstb.2015.0362
关键词
economy; graph theory; hub; Allen Institute for Brain Sciences; transcriptome; community structure
类别
资金
- MRC Bioinformatics Research Fellowship [MR/K020706/1]
- Wellcome Trust
- University College London
- Neuroscience in Psychiatry Network (NSPN)
- NIHR Cambridge Biomedical Research Centre
- Gates Cambridge PhD studentship
- University of Cambridge MB/PhD programme
- Medical Research Council [G1000183B, G1000183, G1100464, MR/K020706/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10051, NF-SI-0514-10157] Funding Source: researchfish
- MRC [G1100464, G1000183, MR/K020706/1] Funding Source: UKRI
Human functional magnetic resonance imaging (fMRI) brain networks have a complex topology comprising integrative components, e.g. long-distance inter-modular edges, that are theoretically associated with higher biological cost. Here, we estimated intra-modular degree, inter-modular degree and connection distance for each of 285 cortical nodes in multi-echo fMRI data from 38 healthy adults. We used the multivariate technique of partial least squares (PLS) to reduce the dimensionality of the relationships between these three nodal network parameters and prior microarray data on regional expression of 20 737 genes. The first PLS component defined a transcriptional profile associated with high intra-modular degree and short connection distance, whereas the second PLS component was associated with high inter-modular degree and long connection distance. Nodes in superior and lateral cortex with high inter-modular degree and long connection distance had local transcriptional profiles enriched for oxidative metabolism and mitochondria, and for genes specific to supragranular layers of human cortex. In contrast, primary and secondary sensory cortical nodes in posterior cortex with high intra-modular degree and short connection distance had transcriptional profiles enriched for RNA translation and nuclear components. We conclude that, as predicted, topologically integrative hubs, mediating long-distance connections between modules, are more costly in terms of mitochondrial glucose metabolism. This article is part of the themed issue 'Interpreting BOLD: a dialogue between cognitive and cellular neuroscience'.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据