期刊
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
卷 146, 期 -, 页码 21-27出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbb.2016.04.007
关键词
Cerebral ischemia; Resveratrol; Cell signaling; Learning and memory; Neuroprotection; Hippocampus
资金
- National Natural Science Foundation of China [30900420, 81271162, 81571293, 81071075, 81271217]
- National Century Excellent Talents in University of China [NCET-06-0557]
Ischemic stroke is a primary cause of mortality and disability in the aged population. Resveratrol (Res), a natural polyphenol enriched in plants, presents diverse biological activities, e.g., antiinflammatory and anti-oxidation effects. Here, we evaluated whether Res pretreatment influenced focal cerebral ischemia-induced cognitive impairment, and we explored the underlying mechanisms in rats. The results showed that a single administration of Res (30 mg/kg, i.p.) at 1 or 4 h, but not at 24 h before focal cerebral ischemia exerted significant neuroprotective effects, including a reduction in hippocampal CA1 neuronal death and spatial cognition deficits caused by ischemia. The neuroprotective effects of Res were suppressed by pretreatment with MK801, an NMDA receptor blocker, or U0126, an extracellular signal regulated kinase 1/2 (ERK1/2) kinase inhibitor. A western blot analysis revealed that Res treatment at 1 h before ischemia significantly increased ERK1/2 phosphorylation and cyclic-AMP response element binding protein (CREB) phosphorylation in the CA1 region of the hippocampus, which can be prevented with U0126 pretreatment. The results showed that the NMDA receptor-mediated ERK-CREB signaling pathway might participates in Res-induced neuroprotection in rats with focal cerebral ischemia. (C) 2016 Elsevier Inc All rights reserved.
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