期刊
PHARMACOLOGY & THERAPEUTICS
卷 163, 期 -, 页码 94-108出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2016.03.013
关键词
Tumor emboli; Apoptosis; High-throughput screening; Inflammatory breast cancer; Oxidative stress; Invasion
资金
- Duke Cancer Institute [NIH CA014236]
- Department of Defense [W81XWH-13-1-0047]
Cancer cells propagated in three-dimensional (3D) culture systems exhibit physiologically relevant cell-cell and cell-matrix interactions, gene expression and signaling pathway profiles, heterogeneity and structural complexity that reflect in vivo tumors. In recent years, development of various 3D models has improved the study of host-tumor interaction and use of high-throughput screening platforms for anti-cancer drug discovery and development. This review attempts to summarize the various 3D culture systems, with an emphasis on,the most well characterized and widely applied model multicellular tumor spheroids. This review also highlights the various techniques to generate tumor spheroids, methods to characterize them, and its applicability in cancer research. (C) 2016 Elseviet Inc. All rights reserved.
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