期刊
PHARMACOLOGY & THERAPEUTICS
卷 164, 期 -, 页码 82-96出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2016.04.002
关键词
Asthma; GPCR; Bronchodilation; Airway smooth muscle; Biased agonism; Inhaled corticosteroids
资金
- NIH [R01 HL58506, R01 AI110007, P01 HL114471]
Despite over 50 years of inhaled beta-agonists and corticosteroids as the default management or rescue drugs for asthma, recent research suggests that new therapeutic options are likely to emerge. This belief stems from both an improved understanding of what causes and regulates airway smooth muscle (ASM) contraction, and the identification of new targets whose inhibition or activation can relax ASM. In this review we discuss the recent findings that provide new insight into ASM contractile regulation, a revolution in pharmacology that identifies new ways to tune G protein-coupled receptors to improve therapeutic efficacy, and the discovery of several novel targets/approaches capable of effecting bronchoprotection or bronchodilation. (C) 2016 Elsevier Inc. All rights reserved.
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