期刊
PHARMACOLOGY & THERAPEUTICS
卷 160, 期 -, 页码 84-132出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2016.02.005
关键词
RF-amide neuropeptides; RF-amide receptors; Feeding; Reproduction; Pain; Drug discovery
资金
- CNRS
- INSERM
- Universite de Strasbourg
- Conectus
- Agence Nationale de la Recherche [ANR-13-BSV1-0001]
- French government
- Agence Nationale de la Recherche (ANR) [ANR-13-BSV1-0001] Funding Source: Agence Nationale de la Recherche (ANR)
RF-amide neuropeptides, with their typical Arg-Phe-NH2 signature at their carboxyl C-termini, belong to a lineage of peptides that spans almost the entire life tree. Throughout evolution, RF-amide peptides and their receptors preserved fundamental roles in reproduction and feeding, both in Vertebrates and Invertebrates. The scope of this review is to summarize the current knowledge on the RF-amide systems in Mammals from historical aspects to therapeutic opportunities. Taking advantage of the most recent findings in the field, special focus will be given on molecular and pharmacological properties of RF-amide peptides and their receptors as well as on their implication in the control of different physiological functions including feeding, reproduction and pain. Recent progress on the development of drugs that target RF-amide receptors will also be addressed. (C) 2016 Elsevier Inc. All rights reserved.
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