期刊
PHARMACOLOGICAL RESEARCH
卷 111, 期 -, 页码 642-651出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2016.07.026
关键词
Hydrogen sulfide; Thiol-based redox switches; Hydropersulfide
资金
- German Research Foundation [SFB 815, SFB 1039, EXC 115, EXC 147, PF361/7-1]
During the last decades, small inorganic molecules like reactive oxygen species (ROS), nitric oxide (NO), carbon monoxide (CO) and even the highly toxic hydrogen sulfide (H2S) have been evolved as important signaling molecules that trigger crucial cellular processes by regulating the activity of kinases, phosphatases and transcription factors. These redox molecules use similar target structures and therefore, the composition of the complex redox environment determines the final outcome of signaling processes and may subsequently also affect the behavior of a cell in an inflammatory environment. Here, we discuss the role of H2S in this complex interplay with a focus on the transcription factors Nrf2 and NF kappa B. (C)2016 Elsevier Ltd. All rights reserved.
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