期刊
PHARMACOLOGICAL RESEARCH
卷 111, 期 -, 页码 152-154出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2016.05.015
关键词
Cellular senescence; Frailty; Insulin resistance; Senolytics
资金
- NIH [AG013925, AG044396, AG19899]
- Robert and Arlene Kogod Center on Aging
- Connor Group
- Ted Nash Foundation
- Glenn/American Federation for Aging Research Postdoctoral Fellowship for Translational Research on Aging
Senescent cells accumulate in a variety of tissues with aging. They can develop a senescence-associated secretory phenotype (SASP) that entails secretion of inflammatory cytokines, chemokines, proteases, and growth factors. These SASP components can alter the microenvironment within tissues and affect the function of neighboring cells, which can eventually lead to local and systemic dysfunction. The JAK pathway is more highly activate in senescent than non-senescent cells. Inhibition of the JAK pathway suppresses the SASP in senescent cells and alleviates age-related tissue dysfunction. Targeting senescent cells could be a promising way to improve healthspan in aged population. (C) 2016 Elsevier Ltd. All rights reserved.
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