期刊
PHARMACOLOGICAL RESEARCH
卷 106, 期 -, 页码 27-36出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phrs.2016.01.001
关键词
Cisplatin resistance; Nucleotide excision repair; ERCC1; Copper transporters; ABC transporters; Glutathione
资金
- Intramural Research Program of the NIH, National Institute on Minority Health and Health Disparities
Cisplatin is one of the most commonly used chemotherapy drugs, treating a wide range of cancer types. Unfortunately, many cancers initially respond to platinum treatment but when the tumor returns, drug resistance frequently occurs. Resistance to cisplatin is attributed to three molecular mechanisms: increased DNA repair, altered cellular accumulation, and increased drug inactivation. The use of precision medicine to make informed decisions on a patient's cisplatin resistance status and predicting the tumor response would allow the clinician to tailor the chemotherapy program based on the biology of the disease. In this review, key biomarkers of each molecular mechanism will be discussed along with the current clinical research. Additionally, known polymorphisms for each biomarker will be discussed in relation to their influence on cisplatin resistance. Published by Elsevier Ltd.
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