期刊
CHEMISTRY-AN ASIAN JOURNAL
卷 10, 期 11, 页码 2427-2436出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201500732
关键词
anti-inflammatory agents; drug design; gels; safins; supramolecular chemistry
资金
- Department of Bio-technology (DBT), New Delhi (DBT) [BT/01/CEIB/11V/13]
- Council of Scientific and Industrial Research (CSIR), New Delhi (CSIR) [09/080(0876/2013-EMR-I]
By exploiting salt formation, a new series of primary ammonium monocarboxylate salts of a nonsteroidal anti-inflammatory drug, namely, diflunisal, was synthesized. The majority of the salts thus synthesized turned out to be good gelators of various solvents, including the solvents (e.g., methyl salicylate and pure water) typically used for topical gel formulation. Single-crystal X-ray diffraction studies of a few gelator and nongelator salts in the series revealed details of the hydrogen-bonding networks present in the salts. Furthermore, one such gelator salt, namely, the diflunisal salt of serinol, was found to be biocompatible (MTT assay), and its anti-inflammatory (PGE(2) assay) response turned out to be as good as that of the parent drug, which is indicative of its potential in biomedical applications.
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