期刊
PEDIATRIC NEUROLOGY
卷 61, 期 -, 页码 94-98出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.pediatrneurol.2016.05.001
关键词
histologic chorioamnionitis; fetal inflammatory response syndrome; brain injury; premature infants; cytokine
资金
- Jiangsu Province's Scientific and Technological Supporting Program [BL2012058]
BACKGROUND: To determine the association of histologic chorioamnionitis (HCA) and fetal inflammatory response syndrome (FIRS) with brain injuries in infants born to mothers with preterm premature rupture of membranes. METHODS: A total of 103 singleton infants born to mothers with preterm premature rupture of membranes were enrolled. The placental inflammation was confirmed by HCA, and FIRS was defined in fetuses with preterm labor and an elevation of the fetal plasma interleukin-6 concentration. Examination of brain images was conducted to confirm the existence of brain injuries. Based on placental HCA and umbilical cord blood interleukin-6 level, all patients were divided into three groups: HCA(-)FIRS(+), HCA(+)FIRS(-), and HCA(+)FIRS(+). RESULTS: Among all infants with preterm premature rupture of membranes, 53.40% were exposed to HCA, 20.38% experienced FIRS, and the overall incidence of brain injuries was 38.83%. The incidence of brain injury in HCA(-)FIRS(+), HCA(+)FIRS(-), and HCA(+)FIRS(+) groups were 20.83%, 41.18%, and 76.19%, respectively. HCA at the advanced grades and stages was associated with increased risk of brain injury. Umbilical cord blood levels of interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor alpha (TNF-alpha), and granulocyte-colony stimulating factor (G-CSF) in premature infants with brain injuries were significantly higher than in those, without brain injuries. Infants diagnosed with both HCA and FIRS showed significantly higher levels of IL-8, TNF-alpha, and G-CSF than those with HCA alone. CONCLUSIONS: Preterm infants exposed to severe chorioamnionitis had an increased risk of brain injury. IL-6, IL-8, TNF-alpha, and G-CSF in cord blood were associated with brain injuries in preterm infants and may be used as extradiagnostic criteria.
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