期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 46, 页码 16395-16399出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201503533
关键词
amidation; CH functionalization; CN bond formation; cobalt; purine compounds
资金
- National Basic Research Program of China (973 Program) [2015CB856600]
- National Science Foundation of China [21325206, 21172006]
- National Young Top-notch Talent Support Program
A cationic cobalt(III)-catalyzed direct CH amidation of unactivated (hetero)arenes and alkenes by using 1,4,2-dioxazol-5-ones as the amidating reagent has been developed. This transformation proceeds efficiently under external oxidant-free conditions with a broad substrate scope. Moreover, 6-arylpurine compounds, which often exhibit high potency in antimycobacterial, cytostatic, and anti-HCV activities, can be smoothly amidated, thus offering a mild protocol for their late stage functionalization.
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