期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 21, 期 14, 页码 5380-5386出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201405931
关键词
catalysis; C-H activation; heterocycles; reaction mechanisms; ruthenium
资金
- Swedish Research Council (Vetenskapsradet)
- Engineering and Physical Sciences Research Council [EP/K03927X/1] Funding Source: researchfish
- EPSRC [EP/K03927X/1] Funding Source: UKRI
The Ru-catalysed C2-H arylation of indoles and pyrroles by using boronic acids under oxidative conditions is reported. This reaction can be applied to tryptophan derivatives and tolerates a wide range of functional groups on both coupling partners, including bromides and iodides, which can be further derivatised selectively. New indole based ruthenacyclic complexes are described and investigated as possible intermediates in the reaction. Mechanistic studies suggest the on-cycle intermediates do not possess a para-cymene ligand and that the on-cycle metalation occurs through an electrophilic attack by the Ru centre.
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